For patients suffering from chronic heartburn, Gastro-Esophageal Reflux Disease (GERD), ulcers, and other digestive disorders, the Proton Pump Inhibitor (PPI) quickly became a sensational centerpiece in the arsenal to combat painful stomach acid symptoms. Additionally, PPIs have enjoyed aggressive marketing by global drug manufacturing giants and have soared to annual market value in excess of $5.6 billion. Today, there are several types of PPIs on the market with some available either Over the Counter (OTC) or by prescription. Now, with several years of both prescription and OTC consumption documented, researchers and physicians are openly talking about the risks associated with long-term use of PPIs. Furthermore, their studies have engendered a more in-depth conversation about whether or not PPIs are necessary for the treatment of more common heartburn symptoms which can be addressed by other medications and or lifestyle changes.