Last Updated November 18, 2020 Proton Pump Inhibitors (PPIs) are drugs that limit the production of digestive acid in the stomach wall. They work by disrupting key enzymes which in turn prevent certain cells in the stomach lining from pumping acid. PPIs are available both by prescription and in over-the-counter (OTC) formats. While PPIs have … Continue reading Proton Pump Inhibitors (PPIs) and Common Drug Interactions